The links below lead to more information about Federal and international laws, regulations and guidelines relevant to regulatory toxicology testing.

Links to general U.S. Federal Regulations and Rules

Links to International (OCED and ECVAM) Guidances and Documents

Method-Specific Guidelines, Regulations and Laws

• Acute Oral Toxicity
  
  • Up-and-Down Procedure
  • In Vitro Methods for Assessing Acute Systemic Toxicity
  
  
• Dermal Corrosivity and Irritation


• Developmental Toxicity


• Endocrine Disruptor


• Immunotoxicity


• Ocular Toxicity


• Phototoxicity
  
  • 3T3 NRU Phototoxicity Test


• Pyrogenicity
  

ICCVAM Guidelines and Processes

• Guidelines for the Nomination and Submission of New, Revised, and Alternative Test Methods


• Test Method Review Process


• Validation and Acceptance Criteria


• ICCVAM Procedures for Test Methods that Have Been Endorsed by ECVAM
  (adopted by ICCVAM, 04-23-01)