Public Health
NICEATM-ICCVAM Home >> Testing Regulations and Guidelines >> Dermal Corrosivity and Irritation

Dermal Corrosivity and Irritation
Site Map
Site Map

Documents may also be found via the Agency Guidelines and Regulations Search Page

Consumer Product Safety Commission (CPSC)

  • U.S. Code of Federal Regulations (CFR)
    • 16 CFR 1500 - Hazardous Substances and Articles; Administration and Enforcement Regulations
      • 16 CFR 1500.3 - Definitions (includes definitions for "hazardous substances", "corrosive", "irritant", etc.) [PDF]
      • 16 CFR 1500.4 - Human experience with hazardous substances [PDF]
      • 16 CFR 1500.41 - Method of testing primary irritant substances [PDF]

U.S. Department of Transportation (DOT) Regulations

  • Exemption DOT-E-10904 (Seventh Revision) - Allows use of Corrositex® as alternative test method [PDF]
  • Code of Federal Regulations:
    • 49 CFR 172.442 - Hazardous Materials: Labeling of Corrosive Substances - Placement [PDF]
    • 49 CFR 172.558 - Hazardous Materials: Labeling of Corrosive Substances - Appearance [PDF]
    • 49 CFR 173.136 - General Requirements for Shipments and Packagings: Class 8 Definitions (criteria for determining classifications of corrosive materials) [PDF]
    • 49 CFR 173.137 - General Requirements for Shipments and Packagings: Assignment of packing group and hazard zones for Division 8 materials (corrosives and irritants) [PDF]

U.S. Environmental Protection Agency (EPA)

  • EPA Test Method 1120 - Dermal Corrosion [PDF]
  • Office of Prevention, Pesticides and Toxic Substances Health Effects Test Guideline: OPPTS 870.2500 - Acute Dermal Irritation (August 1998) [PDF]
  • Code of Federal Regulations:
    • 40 CFR 152.170 - Criteria for restriction to use by certified applicators (criteria includes corrosivity) [PDF]
    • 40 CFR 156.10 - Labeling requirements (skin corrosives are in toxicity category I) [PDF]
    • 40 CFR 157 (Subpart B) - Child-Resistant Packaging (157.22 pesticides corrosive to eyes or skin) [PDF]
    • 40 CFR 261.22 - Characteristic of Corrosivity [PDF]

Organisation for Economic Co-operation and Development (OECD)

  • OECD Guideline for the Testing of Chemicals Number 404: Acute Dermal Irritation/Corrosion (April 2002) [PDF]
  • OECD Guideline for the Testing of Chemicals Number 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (April 2004) [PDF]
  • OECD Guideline for the Testing of Chemicals Number 431: In Vitro Skin Corrosion: Human Skin Model Test (April 2004) [PDF]
  • OECD Guideline for the Testing of Chemicals Number 435: In Vitro Membrane Barrier Test Method for Skin Corrosion (July 2006) [PDF]
  • OECD Guideline for the Testing of Chemicals Number 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method (July 2010) [PDF]

U.S. Occupational Safety and Health Adminstration

  • Code of Federal Regulations:
    • 29 CFR 1910.1200 - Hazard Communication
      Appendix A (pg 473)- Health Hazard Definitions (definition of corrosive is item 2 of Appendix A) [PDF]
  Back to Top NICEATM-ICCVAM:
Advancing Public Health and Animal Welfare
USA.gov is the U.S. government's official web portal to all federal, state, and local government web resources and services U.S. Department of Health and Human Services
The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.