The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM or "the Center") was established in 1998 to:

• Administer ICCVAM and its scientific advisory committee
• Provide technical/scientific support and coordination for ICCVAM and ICCVAM working groups, peer review panels, expert panels, workshops, validation efforts, and the scientific advisory committee
• Organize committee-related activities, such as peer reviews and workshops for test methods of interest to U.S. Federal agencies
• Provide a mechanism for communication between agencies as well as between agencies and test method developers

NICEATM, in providing support for the ICCVAM, also: a) evaluates new test method submissions and nominations for their adherence to ICCVAM guidelines, b) assesses the completeness of test method dossiers for ICCVAM evaluation, c) determines the suitability of test methods for ICCVAM evaluation of their validation status, and d) assembles information about current best practices for the humane care and use of animals in toxicological research and testing.

As resources allow, NICEATM also conducts validation studies to evaluate potential new alternative methods that may reduce, replace, or refine animal use for toxicity testing and provide improved predictability of human or animal toxicity or of adverse ecological effects.

NICEATM and ICCVAM seek to promote the validation and regulatory acceptance of toxicological test methods that will enhance their member agencies' ability to assess risks and make decisions, and that will refine, reduce, and/or replace animal use. The ultimate goal is the validation and regulatory acceptance of test methods that are more predictive of adverse human and ecological effects than currently available methods, supporting improved protection of human health and the environment.