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2012
Announcement Date Announcement Comment or Action Deadline
April 13, 2012 NICEATM Requests Nominations of High Throughput Assays for Tox21

View information on the NICEATM support of the Tox21 Initiative
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April 10, 2012 USDA Seeks Comments on Draft Proposed Guidance Document on the Use of Humane Endpoints and Methods in Animal Testing of Biological Products

View information on the NICEATM-ICCVAM Rabies Vaccine Workshop
April 23, 2012
March 6, 2012 NICEATM-ICCVAM Presentations at the 51st Annual Meeting of the Society of Toxicology

View NICEATM-ICCVAM presentations
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February 27, 2012 ICCVAM Recommendations on the Usefulness and Limitations of the LLNA for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans: Federal Agency Responses Now Available -
February 14, 2012 ICCVAM Evaluation Report and Recommendations Available on the LUMI–CELL® ER (BG1Luc ER TA) Test Method for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals -
January 3, 2012 NICEATM-ICCVAM Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing:
Workshop Report Now Available
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2011
Announcement Date Announcement Comment or Action Deadline
November 21, 2011 Update of the NICEATM-ICCVAM Five-Year Plan: Request for Comments Submit comments by:
January 15, 2012
September 13, 2011 International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing -
August 26, 2011 NICEATM-ICCVAM Presentations at Eighth World Congress on Alternatives and Animal Use in the Life Sciences, August 2011 -
August 12, 2011 ICCVAM Proposes Procedures to Reduce Animal Use for Eye Safety Testing: Request for Comments Submit comments by:
September 26, 2011
July 28, 2011 Recommendations on the Usefulness and Limitations of the LLNA for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans -
May 23, 2011 Nomination of In Vitro Test Methods for Detection and Quantification of Botulinum Neurotoxins and Detection of Non-Endotoxin Pyrogens:
Request for Comments and/or Data
Submit comments by:
July 7, 2011
May 18, 2011 Evaluation of an In Vitro Estrogen Receptor Transcriptional Activation Test Method for Endocrine Disruptor Chemical Screening:
Independent Scientific Peer Review Panel Report Now Available
Submit comments by:
July 5, 2011
May 16, 2011 International Workshop on Alternative Methods for Rabies Vaccine Potency Testing Planned for October 2011 Submit abstracts by:
September 16, 2011

Register by:
September 30, 2011
April 26, 2011 Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods Exiting NICEATM-ICCVAM Website Submit comments by:
June 9, 2011
April 13, 2011 Agency Responses to ICCVAM Recommendations on In Vitro Ocular Safety Testing Methods and Strategies and Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints for Ocular Safety Testing -
February 1, 2011 50th Annual Meeting of the Society of Toxicology, March 6-10
View NICEATM-ICCVAM Presentations
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February 1, 2011 ICCVAM Workshops on Best Practices for Regulatory Safety Testing:
Workshop Presentations and Archived Webcasts Now Available
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January 24, 2011 ICCVAM Peer Review Panel Meeting: Evaluation of an In Vitro Estrogen Receptor Transcriptional Activation Test Method for Endocrine Disruptor Chemical Screening Submit comments by:
March 10, 2011
Register to attend by:
March 10, 2011
January 13, 2011 Agency Responses to ICCVAM Recommendations on Nonradioactive Versions of the Murine Local Lymph Node Assay and Expanded Uses of the Murine Local Lymph Node Assay for Pesticide Formulations and Other Products -
2010
Announcement Date Announcement Comment or Action Deadline
September 17, 2010 ICCVAM International Workshop on
Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing:
Workshop Presentations Now Available
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September 17, 2010 ICCVAM Announces Availability of Test Method Evaluation Reports on In Vitro Ocular Safety Testing Methods and Strategies, and Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints for Ocular Safety Testing -
June 29, 2010 ICCVAM Announces Availability of Test Method Evaluation Reports on Nonradioactive Versions of the Murine Local Lymph Node Assay and Expanded Uses of the Murine Local Lymph Node Assay for Pesticide Formulations and Other Products -
June 10, 2010 ICCVAM Biennial Progress Report 2008-2009 Now Available -
May 12, 2010 Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods Exiting NICEATM-ICCVAM Website June 10, 2010
May 10, 2010 Agency Responses to ICCVAM Recommendations on the Reduced LLNA and LLNA Performance Standards Now Available -
May 10, 2010 International Workshop on Alternative Methods To Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the Science and Future Directions Abstract Submission: July 29, 2010
Registration: August 30, 2010
2009
Announcement Date Announcement Comment or Action Deadline
November 27, 2009 Evaluation of Endocrine Disruptor Screening Assays: Expert Panel Nominations and Data Submissions Requested January 11, 2010
September 30, 2009 ICCVAM Announces Availability of Performance Standards for the Murine Local Lymph Node Assay -
September 30, 2009 ICCVAM Announces Recommendations for the Reduced Murine Local Lymph Node Assay -
September 21, 2009 ECVAM Invites Laboratories to Participate in Prevalidation of In Vitro Test Methods to Evaluate Skin Sensitization Potential October 10, 2009
September 10, 2009 ICCVAM-recommended Nonanimal Ocular Safety Testing Methods Accepted as OECD Test Guidelines -
July 13, 2009 Peer Review Panel Meeting on Alternative Ocular Safety Testing Methods - Peer Review Panel Report Available August 28, 2009
June 1, 2009 Second Meeting of the LLNA Peer Review Panel - Peer Review Panel Report Available July 15, 2009
May 26, 2009 Peer Review Panel Meeting on Alternative Ocular Safety Testing Methods - Meeting Summary Available -
May 5, 2009 Second Meeting of the LLNA Peer Review Panel - Meeting Summary Available -
April 27, 2009 Memorandum of Cooperation signed to establish the International Cooperation on Alternative Toxicological Methods -
April 1, 2009 Peer Review Panel Meeting on Alternative Ocular Safety Testing Methods - Availability of Draft Documents May 15, 2009
Feb. 27, 2009 Announcing Second Meeting of the LLNA Peer Review Panel - Availability of Draft Documents April 14, 2009
Feb. 5, 2009 View NICEATM-ICCVAM Abstracts to be presented at the 2009 Society of Toxicology Meeting -
2008
Announcement Date Announcement Comment or Action Deadline
November 24, 2008 Availability of the ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products and Final Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products; Notice of Transmittal of ICCVAM Test Method Recommendations to Federal Agencies -
October 16, 2008 ICCVAM 2006-2007 Biennial Report now available -
September 4, 2008 Acceptance of ICCVAM-Recommended Ocular Safety Methods Featured in Journal Environmental Health Perspectives -
August 25, 2008 ICCVAM Preparation of OECD Test Guidelines for In Vitro Ocular Test Methods -
June 23, 2008 Press Release: Newly Approved Ocular Safety Methods Reduce Animal Testing -
June 15, 2008 Update on U.S. regulatory acceptance of alternative methods -
May 20, 2008 Independent Scientific Peer Review Panel Report on the Murine Local Lymph Node Assay now available July 7, 2008
Apr. 7, 2008 Non-Animal Assessment Approach for Evaluating Eye Irritation Potential for Anti-Microbial Cleaning Products: Request for Nominations for an Independent Expert Panel and Submission of Relevant Data May 19, 2008
Apr. 2, 2008 View NICEATM-ICCVAM Posters presented at the 2008 Society of Toxicology Meeting -
March 25, 2008 ICCVAM Recommendations on Use of In Vitro Cytotoxicity Assays for Estimating Acute Systemic Toxicity -
Mar. 18, 2008 Materials from the February 2008 Scientific Workshop on Acute Chemical Safety Testing now available -
Feb. 29, 2008 ICCVAM Recommendations on Use of In Vitro Cytotoxicity Assays for Estimating Acute Systemic Toxicity -
Feb. 5, 2008 Availability of the NICEATM-ICCVAM Five-Year Plan -
Jan. 8, 2008 Independent Scientific Peer Review Panel Meeting on the Murine Local Lymph Node Assay; Availability of Draft Background Review Documents; Request for Comments Registration: February 20, 2008
Comments: February 22, 2008
2007
Announcement Date Announcement Comment or Action Deadline
Dec. 6, 2007 Workshop on Acute Chemical Testing Registration: January 22, 2008
Nov. 26, 2007 ICCVAM Releases Test Method Evaluation Report and final Background Review Documents (BRDs) on In Vitro Ocular Test Methods for Identifying Corrosives and Severe Irritants; Recommendations Transmitted to Federal Agencies -
Nov 15, 2007 ICCVAM Tenth Anniversary Symposium Registration: January 25, 2008
Oct 25, 2007 ICCVAM Recommendations on In Vitro Test Methods for Detecting Ocular Corrosives and Severe Irritants -
Sep 12, 2007 Draft Performance Standards for the Murine Local Lymph Node Assay: Request for Comments Comment: Oct 29, 2007
Aug 16, 2007 View NICEATM/ICCVAM Presentations at the Sixth World Congress on Alternatives and Animal Use in the Life Sciences -
June 7, 2007 Request for Ocular Irritancy Test Data From Human, Rabbit, and In Vitro Studies Using Standardized Testing Methods Data Submission: July 23, 2007
May 17, 2007 The Murine Local Lymph Node Assay: Request for Comments, Nominations of Scientific Experts, and Submission of Data Data Submission, Comments and Nominations: June 15, 2007
May 9, 2007 Request for Data on the Use of Topical Anesthetics and Systemic Analgesics for In Vivo Eye Irritation Testing Data Submission: June 25, 2007
May 9, 2007 Submit Public Comments on the Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products Comment: June 25, 2007
May 7, 2007 Availability of the Draft NICEATM-ICCVAM Five-Year Plan Comment: June 7, 2007
May 2, 2007 Availability of the Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products -
Apr. 6, 2007 Town Meeting to Receive Public Comment on the Draft NICEATM-ICCVAM Five-Year Plan Registration: June 7, 2007

Comment: June 7, 2007
2006
Announcement Date Announcement Comment or Action Deadline
Dec. 11, 2006 Announcement of an Independent Scientific Peer Review Meeting on the Use of In Vitro Pyrogenicity Testing Methods; Request for Comments
Registration: Jan. 23, 2007

Comment: Jan. 26, 2007
Nov. 30, 2006 ICCVAM Releases Test Method Evaluation Report and Background Review Document (BRD) on In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity -
Nov. 17, 2006 ICCVAM releases Biennial Progress Report -
Nov. 13, 2006 Request for Public Comments on
The Development of a 5-Year Plan to Research, Develop, Translate, and Validate New and Revised Non-animal and Other Alternative Assays for Integration of Relevant and Reliable Methods into Federal Agency Testing Programs
Comment: Dec. 31, 2006
Nov. 1, 2006 Availability of the Pre-Publication Release:
ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test Method for Estimating Starting Doses for Acute Oral Systemic Toxicity
and the
In Vitro Acute Toxicity Test Methods Background Review Document (BRD)

For consideration at the November 30, 2006, meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM)
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Nov. 16, 2006 Availability of the Biennial Progress Report:
Interagency Coordinating Committee on the Validation of Alternative Methods
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Oct. 16, 2006 Availability of the NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity); Request for Comments and Nominations of Other In Vitro Endocrine Disruptor Test Methods Nov. 30, 2006
Sept. 28, 2006 Availability of the Finalized Addendum To Report:
ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays (NIH Publication No. 03-4503, May 2003)
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Oct. 25, 2006 Availability of the Current Status of In Vitro Test Methods for Detecting Ocular Corrosives and Severe Irritants:

View ICCVAM Ocular Test Method Evaluation Report
and Background Review Documents (BRDs)

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July 11, 2006 Availability of the Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing Aug. 25, 2006

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