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In 2007, NICEATM and ICCVAM developed a Five-Year Plan to:
- Research, develop, translate, and validate new and revised non-animal and other alternative assays
for integration of relevant and reliable methods into Federal agency testing programs
- Identify areas of high priority for new and revised non-animal and alternative assays or batteries of
those assays to create a path forward for the replacement, reduction, and refinement of animal tests, when this
is scientifically valid and appropriate
The Five-Year Plan provided a guide for NICEATM and ICCVAM activities for the years 2008 through 2012.
During the period covered by the Five-Year Plan, ICCVAM made recommendations to Federal agencies
on the use of alternative methods to identify potential pyrogens, skin sensitizers, eye irritants,
and endocrine disruptors. NICEATM and ICCVAM also organized seven workshops to promote development
and appropriate use of alternative test methods, and facilitated increased international cooperation
in the development and adoption of alternative methods. An implementation plan document was
developed and updated regularly to keep ICCVAM stakeholders informed on progress towards the
goals outlined in the Five-Year Plan.
NICEATM-ICCVAM Five-Year Plan
 (January 2008)
Read the 2008-2012 NICEATM-ICCVAM Five-Year Plan in webpage format
Draft Implementation Plan for the ICCVAM Five-Year Plan
(updated June 2012)
The period covered by the 2008–2012 Five-Year Plan is now complete.
Organizational changes within
NICEATM and changes in the direction and focus of the science of toxicology make 2013 an appropriate
time to reassess NICEATM and ICCVAM goals, priorities, and procedures. These reassessment activities
are currently ongoing, and we welcome input from regulators, industry, researchers, test method
developers, and other stakeholders on how NICEATM and ICCVAM can continue to effectively promote the
validation and acceptance of alternative test methods.
Submit a comment to NICEATM
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