ICCVAM Evaluation of EPISKIN^TM, EpiDerm^TM (EPI-200),
and the Rat Skin Transcutaneous Electrical
Resistance (TER) Assay:
In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals

Interagency Coordinating Committee on the
Validation of Alternative Methods (ICCVAM)

National Toxicology Program (NTP) Interagency Center for
the Evaluation of Alternative Toxicological Methods (NICEATM)

Table of Contents

1.0 ICCVAM Evaluation and Test Recommendations

1. Introduction
2. Background
3. ICCVAM Test Method Recommendations

2.0 EPISKIN^TM

1. Summary Report of the EPISKIN^TM Assay
2. EPISKIN^TM Test Method Protocol

3.0 EpiDerm^TM (EPI-200)

1. Summary Report of the EpiDerm^TM (EPI-200) Assay
2. EpiDerm^TM (EPI-200) Test Method Protocol

4.0 Rat Skin Transcutaneous Electrical Resistance (TER) Assay

1. Summary Report of the Rat Skin TER Assay
2. Rat Skin TER Test Method Protocol

5.0 References

Appendices

A.   Federal Regulations and Guidelines for Corrosivity

1. Summary Table of Guidelines and Regulations for Dermal Corrosivity
2. OPPTS 870.2500 Acute Dermal Irritation - U.S. EPA (Health Effects Test Guidelines)
3. Chapter 8 (Precautionary Labeling) - U.S. EPA. OPP

B.   European Commission (EC) Evaluations and Statements

1. Statements by the ECVAM Scientific Advisory Committee (ESAC)
• Statement on Rat Skin TER and EPISKIN^TM
• Statement on EpiDerm^TM
2. Scientific Committee on Cosmetic Products and Non-Food Products (SCCNFP)
• SCCNFP Opinion on In Vitro Skin Corrosivity Methods
• SCCNFP Committee Members
3. EC Directive for Rat Skin TER and a Human Skin Model Assay

C.   OECD Test Guidelines and Documents

• Current or final adopted versions of the Guidelines are available through Source OECD

D.   Federal Register Notice [Vol. 66 (189): 49685-6; Sep. 28, 2001]
   Search for this Federal Register notice

E.   Public Comments
   Search for Public Comments on this Report