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In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives
Expert Panel Report

March 2005

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Table of Contents
In Vitro Ocular Test Method Expert Panel Roster
Preface
Executive Summary

I.   Isolated Rabbit Eye Test Method [PDF, 324 k]

  1. IRE Test Method Rationale
  2. IRE Test Method Protocol Components
  3. Substances Used For Previous Validation Studies of the IRE Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. IRE Test Method Data and Results
  6. IRE Test Method Accuracy
  7. IRE Test Method Reliability (Repeatability/Reproducibility)
  8. Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations (Refinement, Reduction, and Replacement)
  11. Practical Considerations
  12. Proposed Test Method Recommendations
  13. IRE BRD References
  14. Panel Report References

II.  Isolated Chicken Eye Test Method [PDF, 196 k]

  1. ICE Test Method Rationale
  2. ICE Test Method Protocol Components
  3. Substances Used For Previous Validation Studies of the ICE Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. ICE Test Method Data and Results
  6. ICE Test Method Accuracy
  7. ICE Test Method Reliability (Repeatability/Reproducibility)
  8. Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations (Refinement, Reduction, and Replacement)
  11. Practical Considerations
  12. Proposed Test Method Recommendations
  13. ICE BRD References
  14. Panel Report References

III.  Bovine Corneal Opacity and Permeability Test Method [PDF, 252 k]

  1. BCOP Test Method Rationale
  2. BCOP Test Method Protocol Components
  3. Substances Used For Previous Validation Studies of the BCOP Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. BCOP Test Method Data and Results
  6. BCOP Test Method Accuracy
  7. BCOP Test Method Reliability (Repeatability/Reproducibility)
  8. Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations (Refinement, Reduction, and Replacement)
  11. Practical Considerations
  12. Proposed Test Method Recommendations
  13. BCOP BRD References
  14. Panel Report References

IV.  Hen's Egg Test - Chorioallantoic Membrane Test Method [PDF, 216 k]

  1. HET-CAM Test Method Rationale
  2. HET-CAM Test Method Protocol Components
  3. Substances Used For Previous Validation Studies of the HET-CAM Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. HET-CAM Test Method Data and Results
  6. HET-CAM Test Method Accuracy
  7. HET-CAM Test Method Reliability (Repeatability/Reproducibility)
  8. Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations (Refinement, Reduction, and Replacement)
  11. Practical Considerations
  12. Proposed Test Method Recommendations
  13. HET-CAM BRD References
  14. Panel Report References

V.  Recommended Reference Substances for Validation Studies [PDF, 128 k]

  1. Adequacy and Completeness of the Recommended List of Reference Substances
  2. Other Criteria that Should be Addressed in the Selection of Reference Substances

View Addendum to Expert Panel Report
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