September 14-16, 2010
William H. Natcher Conference Center - National Institutes of Health
Bethesda, MD, USA
Workshop Report (published in Procedia in Vaccinology)
View workshop agenda
The goals of this workshop were to:
- Review the state of the science of alternative methods that are
currently available and/or accepted for use that reduce, refine (less
pain and distress), and replace the use of animals in vaccine potency
and safety testing, and discuss ways to promote their
- Identify knowledge and data gaps that must
be addressed to develop alternative methods that can further reduce,
refine, and replace the use of animals in vaccine potency and safety
- Identify and prioritize research, development, and validation efforts needed to address
these knowledge and data gaps in order to advance alternative methods for vaccine potency
and safety testing, while ensuring continued protection of human and animal health.
Nearly two hundred scientists from 13 countries gathered at this workshop to review the current
state of the science and to recommend future research, development, and validation
needed to advance alternative methods that can reduce, refine (decrease or eliminate pain and
distress), and replace the use of animals for human and veterinary vaccine post-licensing potency
and safety testing. The workshop
was organized NICEATM and ICCVAM in partnership with the European Centre for the Validation of
Alternative Methods, the Japanese Center for the Validation of Alternative Methods, and Health
Canada. The workshop was co-sponsored by the Society of Toxicology.
Vaccines represent a vital and cost-effective tool in the prevention of numerous infectious
diseases. The importance of vaccines to human and animal health is underscored by a number of
factors, including increasing occurrence of antibiotic-resistant bacteria, the growing concern about
diseases in domestic animals and wildlife that can be passed on to humans, and the priority given by
the World Health Organization to the eradication of a number of diseases.
In recent years, efforts have increased to develop alternative methods that reduce, refine, and replace the
use of animals for vaccine potency and safety testing. However, these tests still account for the
largest numbers of animals that experience unrelieved pain and distress.
Implementation of the recommendations of this workshop is expected to advance the
availability of alternative methods for vaccine potency and safety testing while ensuring continued
protection of human and animal health.
Additional Workshop Information
Abstracts of posters presented at Sept. 14 poster session
Speaker and panelist biographical information