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May 19-21, 2009
Consumer Product Safety Commission (CPSC) Headquarters
Bethesda, MD
NICEATM, in collaboration with ICCVAM,
convened a public meeting of an independent scientific peer review panel in May 2009.
The Panel evaluated alternative test methods and approaches that may further reduce
and refine the use of animals for ocular safety testing, including:
- A proposal for the routine use of topical anesthetics, systemic analgesics, and humane endpoints to
avoid and minimize pain and distress during in vivo ocular irritation testing
- The validation status of four in vitro test methods for identifying moderate and mild irritants and substances not classified as ocular irritants
- The validation status of the in vivo low volume eye test
- The validation status of a testing strategy that proposes the use of three in vitro test methods to assess eye irritation
potential of antimicrobial cleaning products
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View Meeting Agenda [PDF]
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Dr. Wallace Hayes of the Harvard School of Public Health chaired the public meeting of the Panel,
composed of 22 scientists from the U.S., Japan, Canada, the Netherlands, Belgium, and Spain. The Panel
represented a wide range of expertise, including human and veterinary ophthalmology, in vitro toxicology,
biostatistics, anesthesiology, pathology, and regulatory toxicology.
The Panel's report, including all its
conclusions and recommendations, was published in July. ICCVAM will consider the Panel's report, as well as
comments from the public and from the Scientific Advisory Committee on Alternative Toxicological Methods, as it
develops final recommendations on these topics. Final ICCVAM recommendations are expected to be transmitted
to U.S. Federal agencies in 2010.
View Peer Panel Report [PDF]
View Federal Register Notice announcing the meeting [PDF]
(74 FR 14556, March 31, 2009)
View comments received in
response to the Federal Register notice
View documents reviewed by the Panel
View Peer Review Panel Roster
More information about the NICEATM-ICCVAM evaluation of Ocular Toxicity Test Methods
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