PEER REVIEW PANEL MEETING:
on the Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Toxicity

May 23, 2006

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Additional Materials for Panel Review

• ECBC IC50/LD50 Graph with standard deviations [PDF]
  
  
• Presentation: Correlation of NRU IC50 data with human lethal serum concentrations, by Silvia Casati at the 5th World Congress in Berlin
  
  
• Annotated SAS code for UDP assay simulations [PDF]
  
  
• MATLAB code for ATC assay simulations
  • Description of the OECD Acute Toxic Class Method simulation: [PDF]
    1. toxClassAlg.pdf
    2. doseResponse.pdf
    3. cytosim_mM.pdf
    4. cytosim_mg.pdf
       
       
• IC50-LD50 figures in mmol units [PDF]
  
  
• IC50-LD50 figures in mmol units for 58 RC chemicals [PDF]
  
  
• Accuracy for Prediction of GHS Acute Oral Toxicity Category - All Test Substances [PDF]
  
  
• IC50 Analysis - Maximum:Minimum Ratios
  • All Substances [PDF]
  • Substances with Maximum:Minimum IC50 > 3 [PDF]
    
    
• IC50 vs LD50 Variability
  • Maximum:Minimum Ratios - 3T3 NRU IC50 vs LD50 [PDF]
  • Maximum:Minimum Ratios - NHK NRU IC50 vs LD50 [PDF]
  • Maximum:Minimum Ratios - 3T3 NRU IC50 vs NHK NRU IC50 [PDF]
    
    
• Animal use for simulated in vivo testing - all test substances [PDF]
  
  
• Substance-specific animal use/death data - 46 to 47 substances [PDF or Word]