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NICEATM-ICCVAM Home >> Test Method Evaluations>> Acute Oral Toxicity >> Up-and-Down Procedure

Up-and-Down Procedure for Acute Oral Toxicity
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Recommendations		 Peer Review
Evaluation Report		 Presentations and References

References and Poster Presentations

Poster Presentations

2002

Blackard B, Tice R, Stokes W, Hill R. The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) peer review panel evaluation of the revised Up-and-Down Procedure (UDP) for acute oral toxicity. Fourth World Congress on Alternatives and Animal Use in the Life Sciences. View Poster.

Relevant References

Botham P. 2004. Acute systemic toxicity--prospects for tiered testing strategies.
Toxicology In Vitro 18:227-230.

Meyer S, Marchand A, Hight J, Roberts G, Escalon L, Inouye L, MacMillan D. 2005. Up-and-down procedure (UDP) determinations of acute oral toxicity of nitroso degradation products of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). J Appl Toxicol 25:427-434.
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