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ICCVAM Participation in OECD Test Guidelines for the Detection of Endocrine-Disrupting Substances

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OECD Test Guideline: "The Uterotrophic Bioassay in Rodents: A Short-term Screening Test for Oestrogenic Properties"

NICEATM/ICCVAM Comments on the Proposed Draft OECD Test Guideline:

  • 5 February 2007 Letter to Dr. Jerry Smrchek, U.S. National Coordinator for the OECD Test Guidelines Program, regarding ICCVAM comments on the final draft OECD Test Guideline for the Uterotrophic Bioassay in Rodents [PDF]
  • ICCVAM comments on the final draft OECD Test Guideline for the Uterotrophic Bioassay in Rodents [PDF]
  • ICCVAM comments on revisions of the draft OECD Test Guideline for the Uterotrophic Bioassay in Rodents submitted as discussion items for the OECD Validation Management Group meeting in January 2007 [PDF]
    • ICCVAM comments on first revision of draft OECD Test Guideline for the Uterotrophic Bioassay in Rodents [PDF]
    • ICCVAM comments on initial draft of OECD Test Guideline for the Uterotrophic Bioassay in Rodents [PDF]
    • Supporting information for ICCVAM comments on phytoestrogen content in rodent diets [PDF]

OECD Test Guideline: The Hershberger Bioassay in Rats

NICEATM/ICCVAM Comments on the draft OECD Test Guideline:

  • 15 June 2007 letter to Dr. Jerry Smrchek, U.S. National Coordinator for the OECD Test Guidelines Program, regarding ICCVAM comments on the draft Test Guideline [PDF]
  • NICEATM/ICCVAM Comments on the draft Test Guideline [PDF]

OECD Test Guideline: Updated Test Guideline 407, Repeated Dose 28-Day Oral Toxicity Study in Rodents

NICEATM/ICCVAM Comments on the draft OECD Test Guideline:

  • 6 August 2007 letter to Dr. Jerry Smrchek, U.S. National Coordinator for the OECD Test Guidelines Program, regarding ICCVAM comments on the draft Test Guideline [PDF]
  • NICEATM/ICCVAM Comments on the draft Test Guideline [PDF]

OECD Test Guideline: Stably Transfected Transcriptional Activation (STTA) Assay for Detecting Estrogenic Activity of Chemical

NICEATM/ICCVAM Comments on the draft OECD Test Guideline:

  • 14 August 2007 letter to Dr. Jerry Smrchek, U.S. National Coordinator for the OECD Test Guidelines Program, regarding ICCVAM comments on the draft Test Guideline [PDF]
  • NICEATM/ICCVAM Comments on the draft Test Guideline [PDF]

NICEATM/ICCVAM Submission of the Stably Transfected Transcriptional Activation Assay for the Detection of Estrogen Receptor Agonists and Antagonists to the OECD Test Guidelines Program

  • 14 September 2007 letter to Dr. Jerry Smrchek, U.S. National Coordinator for the OECD Test Guidelines Program, regarding submission of the assay [PDF]
  • Completed OECD Standard Project Submission Form for the assay [PDF]

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