1998 Peer Review Panel Meeting
On Sep. 17, 1998, NICEATM hosted a meeting to review the Murine Local
Lymph Node Assay (LLNA) as an alternative test method for assessing the
allergic contact dermatitis potential of chemicals. The final
peer review report was published in February 1999. The peer review panel
concluded that the LLNA is a valid alternative to currently accepted
guinea pig test methods, and that the LLNA reduces the number of animals
required for testing and eliminates animal pain and distress. Compared
to the traditional test, the LLNA can also be completed in a shorter
timeframe and provides dose-response information.
ICCVAM Peer Review Report
The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds:
The Results of an Independent Peer Review Evaluation Coordinated by the Interagency
Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
and the National Toxicology Program Center for the Evaluation of Alternative Toxicological
Methods (NICEATM).
February 1999 NIH Publication No. 99-4494
View report in PDF format - 9.2 MB
View Table of Contents in HTML format
Transmittal of ICCVAM Recommendations
Letter from Dr. Kennenth Olden, Director, NIEHS, to Ms. Carol Browner, Administrator, U.S. EPA,
transmitting results of the independent peer review evalation of the LLNA (sent February 16, 1999)
[PDF]
Response from Dr. Steven Galson, EPA, on behalf of Ms. Browner (received October 19, 1999)
[PDF]
Implementation Workshop
An LLNA Training Workshop, organized by ILSI HESI and ICCVAM,
was held May 25, 2005, at the NIH Natcher Conference Center in
Bethesda, MD. For additional information, please contact ILSI HESI at
hesi@ilsi.org.
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