|
In September 1998, NICEATM hosted a meeting to review the murine local
lymph node assay (LLNA) as an alternative test method for assessing the
allergic contact dermatitis potential of chemicals in humans. The final
peer review report was published in February 1999. The peer review panel
concluded that the LLNA is a valid alternative to currently accepted
guinea pig test methods, and that the LLNA reduces the number of animals
required for testing and eliminates animal pain and distress. Compared
to guinea pig tests, the LLNA can also be completed in a shorter
timeframe and provides dose-response information.
ICCVAM Peer Review Report: The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds:
The Results of an Independent Peer Review Evaluation Coordinated by the Interagency
Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
and the National Toxicology Program Center for the Evaluation of Alternative Toxicological
Methods (NICEATM).
February 1999 NIH Publication No. 99-4494
View Peer Review Panel report [PDF]
View Table of Contents in HTML format
View Federal Register notice announcing availability
of report (64 FR 14006, March 23, 1999) [PDF]
Notice of Meeting to Review the Murine Local Lymph Node Assay (LLNA) as an Alternative Test Method for Contact Hypersensitivity; Request for Comments
(63 FR 37405, July 10, 1998)
View Federal Register notice [PDF]
View Summary Minutes of the September 1998 Peer Panel Meeting
Transmittal of ICCVAM Recommendations
Letter from Dr. Kennenth Olden, Director, NIEHS, to Ms. Carol Browner, Administrator, U.S. EPA,
transmitting results of the independent peer review evaluation of the LLNA (sent February 16, 1999)
[PDF]
Response from Dr. Steven Galson, EPA, on behalf of Ms. Browner (received October 19, 1999)
[PDF]
Additional Information
Relevant publications published after the
1998 LLNA Peer Review Meeting [PDF]
Press releases:
ECVAM Scientific
Advisory Committee (ESAC) Statement on the Scientific Validity of Local
Lymph Node Assay for Skin Sensitisation Testing. Endorsement made
during 14th Meeting, held on 14 - 15 March 2000 at ECVAM, Ispra, Italy.
Statement released 21 March 2000.
An LLNA Training Workshop, organized by ILSI HESI and ICCVAM,
was held May 25, 2005, at the NIH Natcher Conference Center in
Bethesda, MD. For additional information, please contact ILSI HESI at
hesi@ilsi.org.
|