Background Review Documents	Overview	Peer Review Panel (2008)
Peer Review Panel (1998)	Performance Standards	References
Related Documents	Test Method Recommendations (Draft)

Related Documents

• Protocol: Murine Local Lymph Node Assay (LLNA)
  January 2001: Recommended by ICCVAM Immunotoxicology Working Group, based on an Independent Expert Peer Review Panel Evaluation of the LLNA.



• The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) has published Monograph No. 29 on Skin Sensitisation Testing for the Purpose of Hazard Identification and Risk Assessment, which is now available at the ECETOC Secretariat. The Abstract can be viewed at the ECETOX web site. Contact the Secretary General of ECETOC at info@ecetoc.org.



• Society of Toxicology (SOT) Specialty Section on Dermal Toxicology.



• ECVAM Scientific Advisory Committee (ESAC) Statement on the Scientific Validity of Local Lymph Node Assay for Skin Sensitisation Testing. Endorsement made during 14th Meeting, held on 14 - 15 March 2000 at ECVAM, Ispra, Italy. Statement released 21 March 2000.



• Relevant publications published after the LLNA Peer Review Meeting (1998-present)

Meeting Minutes

• Meeting minutes - Sep. 17, 1998, in Gaithersburg, MD

Federal Register Notices

• Search Federal Register Notices


• Federal Register Notice: LLNA Report Now Available, Mar. 23, 1999 (64 FR 14006)


• Federal Register Notice: Notice of Meeting to Review the Murine Local Lymph Node Assay (LLNA) as an Alternative Test Method for Contact Hypersensitivity; Request for Comments, July 10, 1998 (63 FR 37405).

Press Releases

• Research Institute for Fragrance Materials, Inc. (RIFM):
  • ARTICLE ON ORAL SUBCHRONIC TOXICITY OF AHTN PUBLISHED IN FOOD AND CHEMICAL TOXICOLOGY (September 7, 2004)
    Referenced article:
    Api AM, Smith RL, Pipino S, Marczylo T, and De Matteis F. 2004. Evaluation of the oral subchronic toxicity of AHTN (7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) in the rat. Food and Chemical Toxicology 42:791-801.
  
  
  
  • "RECENT STUDIES CONDUCTED BY RIFM IN SUPPORT OF THE ENVIRONMENTAL RISK ASSESSMENT PROCESS," PUBLISHED IN SYNTHETIC MUSK FRAGRANCES IN THE ENVIRONMENT (September 7, 2004)
    Referenced article:
    Balk F, Salvito D, and Blok H. 2004. Recent Studies Conducted by the Research Institute for Fragrance Materials (RIFM) in Support of the Environmental Risk Assessment Process. The Handbook of Environmental Chemistry 3(X):311-331.
  
  
  
  • ARTICLE ON ETHANOL AND DIETHYL PHTHALATE: VEHICLE EFFECTS IN THE LLNA PUBLISHED IN INTERNATIONAL JOURNAL OF TOXICOLOGY AVAILABLE FOR REPRINT (September 7, 2004)
    Referenced article:
    Lalko J, Isola D and Api AM. 2004. Ethanol and Diethyl Phthalate: Vehicle Effects in the Local Lymph Node Assay. International Journal of Toxicology 23:171-177.
  
  
  
  • ARTICLE ON CHROMOGENIC DERIVATIVES OF AHTN PUBLISHED IN FOOD AND CHEMICAL TOXICOLOGY (September 7, 2004)
    Referenced article:
    Pipino S, Api AM, Pons N, Smith RL, and De Matteis F. 2004. Chromogenic Derivatives of AHTN (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) react with amino acids and protein in vitro. Special characteristics of the colour products. Food and Chemical Toxicology 42:785-790.
  
  
  
  • REPRINTS AVAILABLE FOR ARTICLE ON ENVIRONMENTAL FATE OF FRAGRANCE MATERIALS IN SOIL PUBLISHED IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY (September 3, 2004)
    Referenced article:
    Di Francesco AM, Chiu PC, Standley LJ, Allen HE, and Salvito DT. 2004. Dissipation of Fragrance Materials in Sludge-Amended Soils. Environ Sci Technol 38:194-201.
  
  
  
  • REPRINTS AVAILABLE FOR ARTICLE ON ENVIRONMENTAL IMPACT OF FRAGRANCE MATERIALS PUBLISHED IN FLAVOUR AND FRAGRANCE JOURNAL (September 3, 2004)
    Referenced article:
    Salvito DT, Vey MGH, and Senna RJ. 2004. Fragrance materials and their environmental impact. Flavour Fragr J 19:105-108.
  
  
  
• November 14, 2000: RDS Press Release on the SmithKline Beecham Laboratory Animal Welfare Prize. The ICCVAM organized the independent scientific peer review of the method in 1998, and recommended it to regulatory agencies as a valid substitute for the existing test method. For further information please contact RDS.



• "Good News for Guinea Pigs" (Science Magazine) Oct. 02, 1998



• "New Tricks for an Old Assay" (Environmental Health Perspectives (EHP) Magazine) Oct. 1998



• "U.S. scientists endorse change in animal testing" (originally appeared on CNN Interactive, reproduced with permission from Reuters) Sept. 21, 1998



• New Agency Group to Review Proposed Use of Skin Sensitivity Test Using Fewer Animals (NIEHS) Sept. 10, 1998