National Toxicology Program

Related Documents

NICEATM-ICCVAM Publications

• Poster presentation: Stokes W, Allen D, Burns T, Choksi N, Matheson J. Jacobs A, Tice R Performance Characteristics of the Local Lymph Node Assay (LLNA) Limit Dose Procedure. Presented at the Society of Toxicology 47th Annual Meeting, March 2008. View Poster.


• Protocol: Murine Local Lymph Node Assay (LLNA)
  January 2001: Recommended by ICCVAM Immunotoxicology Working Group, based on an Independent Expert Peer Review Panel Evaluation of the LLNA.

References

• References relevant to the 2007 LLNA Evaluation


• List of relevant publications published after the 1998 LLNA Peer Review Meeting [PDF]


• References from the Research Institute for Fragrance Materials, Inc. (RIFM):
  • Api AM, Smith RL, Pipino S, Marczylo T, De Matteis F. 2004. Evaluation of the oral subchronic toxicity of AHTN (7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) in the rat. Food and Chemical Toxicology 42:791-801.
  • Balk F, Salvito D, Blok H. 2004. Recent Studies Conducted by the Research Institute for Fragrance Materials (RIFM) in Support of the Environmental Risk Assessment Process. The Handbook of Environmental Chemistry 3:311-331.
  • Lalko J, Isola D, Api AM. 2004. Ethanol and Diethyl Phthalate: Vehicle Effects in the Local Lymph Node Assay. International Journal of Toxicology 23:171-177.
  • Pipino S, Api AM, Pons N, Smith RL, De Matteis F. 2004. Chromogenic Derivatives of AHTN (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) react with amino acids and protein in vitro. Special characteristics of the colour products. Food and Chemical Toxicology 42:785-790.
  • Di Francesco AM, Chiu PC, Standley LJ, Allen HE, Salvito DT. 2004. Dissipation of Fragrance Materials in Sludge-Amended Soils. Environ Sci Technol 38:194-201.
  • Salvito DT, Vey MGH, Senna RJ. 2004. Fragrance materials and their environmental impact. Flavour Fragr J 19:105-108.

Press Releases

• RDS Press Release on the SmithKline Beecham Laboratory Animal Welfare Prize (November 2000) -- awarded for development of the LLNA
• "Good News for Guinea Pigs" (Science Magazine) Oct. 02, 1998
• "New Tricks for an Old Assay" (Environmental Health Perspectives (EHP) Magazine) Oct. 1998
• "U.S. scientists endorse change in animal testing" (originally appeared on CNN Interactive, reproduced with permission from Reuters) Sept. 21, 1998
• New Agency Group to Review Proposed Use of Skin Sensitivity Test Using Fewer Animals (NIEHS) Sept. 10, 1998

Other Resources

• Society of Toxicology (SOT) Specialty Section on Dermal Toxicology.
• ECVAM Scientific Advisory Committee (ESAC) Statement on the Scientific Validity of Local Lymph Node Assay for Skin Sensitisation Testing. Endorsement made during 14th Meeting, held on 14 - 15 March 2000 at ECVAM, Ispra, Italy. Statement released 21 March 2000.