NICEATM invites (Federal Register, Vol. 73, No. 66, page 18535-18536, April 4, 2008) the submission of relevant data and information on AMCPs or related substances obtained from

• Human testing or experience, including reports from accidental exposures
• Rabbits using the standard eye test or the low volume eye test
• In vitro test methods for assessing ocular irritation, such as the Bovine Corneal Opacity and Permeability test, the Cytosensor Microphysiometer test, and the EpiOcular test, including data supporting the accuracy and reproducibility of these methods

Although data can be accepted at any time, data received by May 19, 2008, will be considered during the ICCVAM evaluation process. Relevant data received after this date will be considered during the ICCVAM evaluation process, if feasible. All information submitted in response to this notice will be made publicly available and may be incorporated into future NICEATM and ICCVAM reports and publications as appropriate.

When submitting data, please reference the April 4, 2008, Federal Register notice and provide appropriate contact information (name, affiliation, mailing address, phone, fax, e-mail, and sponsoring organization, as applicable).

• Common and trade name
• Chemical Abstracts Service Registry Number (CASRN)
• Chemical and/or product class
• Commercial source
• Physical and chemical properties (e.g. molecular weight, pH, water solubility, etc.)
• In vivo or in vitro test protocol used
• Individual animal or in vitro responses at each observation time (i.e., raw data)
• The extent to which the study complies with national/international Good Laboratory Practice (GLP) guidelines
• Date and testing organization