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In November 2006, NICEATM published recommendations on the use of four in vitro methods for identifying
ocular corrosives and severe irritants:
- The bovine corneal opacity and permeability test method
- The isolated chicken eye test method
- The isolated rabbit eye test method
- The hen's egg test - chorioallantoic membrane test method
One of the ICCVAM recommendations was to consider the validation status of these four in vitro
ocular test methods for identifying mild and moderate ocular irritants and nonirritants. NICEATM and
ICCVAM have prepared draft BRDs assessing the current validation status of the four test methods
for their ability to identify moderate and mild irritants and nonirritants. These documents
were reviewed in May 2009 by an independent international peer review panel.
ICCVAM will consider the peer review panel's comments, as well as comments from the
public and from the Scientific Advisory Committee on Alternative Toxicological Methods, as
it develops its final recommendations for U.S. Federal agencies.
Read the Peer Review Panel Report
[PDF]
Federal Register Notice:
Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing
Methods and Approaches: Notice of Availability and Request for Public Comments (74 FR 33444, July 13, 2009)
View Federal Register notice [PDF]
View comments submitted on Federal Register notice
Federal Register Notice:
Announcement of an Independent Scientific Peer Review Panel on Alternative Ocular Safety
Testing Methods; Availability of Draft Background Review Documents (BRD); Request for Comments (74 FR 14566, March 31, 2009)
View Federal Register notice [PDF]
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