Expert Panel Report
ICCVAM convened
an expert panel meeting on January 11-12, 2005 to consider four in vitro test methods for measuring eye irritancy.
The test methods included:
- The bovine corneal opacity and permeability [BCOP] test method
- The hen's egg test-chorioallantoic membrane [HET-CAM] test method
- The isolated chicken eye [ICE] test method
- The isolated rabbit eye [IRE] test method
NICEATM organized the 24-member international panel in collaboration with the ICCVAM and the European Centre for the Validation of Alternative
Methods (ECVAM). The meeting was held in response to a request by the U.S. EPA for ICCVAM to evaluate the usefulness and limitations of
in vitro ocular safety testing methods.The Panel's conclusions and recommendations are contained in the
Expert Panel Report published in March 2005.
The Panel reconvened for a teleconference in September 2005 to consider additional data and information.
An Addendum to the Expert Panel Report, covering discussions
at the September 2005 teleconference, was published in November 2005
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Expert Panel Report: Evaluation of the Current Validation Status of In Vitro
Test Methods for Identifying Ocular Corrosives and Severe Irritants (March 2005)
Read the Expert Panel Report [PDF]
View webpage listing contents of the Expert Panel Report
Addendum to the Expert Panel Report (November 2005)
Read the Addendum to the Expert Panel Report [PDF]
Ocular Expert Meeting (January 11-12, 2005) Presentations
NOTE: The final expert panel presentations linked to this page represent some of the conclusions and recommendations
of the panel but do not capture the entirety of their discussions and deliberations at the January 2005 meeting. A comprehensive account of the conclusions
and recommendations of this panel is in their final report. These presentations are being made available for
information purposes only and should not be be cited or quoted as the final recommendations of the panel.
Supplemental Information for the January 2005 Expert Panel Meeting:
- NICEATM Draft Report: "Interim Analysis of the Estimated
Potential Underclassification Rates of the Current Rabbit Test for Detecting
Ocular Corrosives and Severe Irritants" (Jan. 6, 2005) [ PDF]
- NICEATM Draft Technical Summary:
"Reduction of the Number of Animals
Required for Ocular Irritancy Testing: A Brief Review of the Literature" [PDF]
View materials for the Ocular Expert Panel Teleconference (September 19, 2005)
Background and Additional Information
- Draft Report: Analysis of the Estimated Underclassification
and Overclassification Likelihoods of the Current
In Vivo Rabbit Eye Test for Hazard Classification (Nov. 4, 2005)
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