Expert Panel Report
ICCVAM convened
an expert panel meeting on January 11-12, 2005 to consider four in vitro test methods
proposed as potential screening methods for ocular corrosion or severe irritation:
- The bovine corneal opacity and permeability test method
- The hen's egg test-chorioallantoic membrane test method
- The isolated chicken eye test method
- The isolated rabbit eye test method
NICEATM organized the 24-member international panel in collaboration with the ICCVAM
and the European Centre for the Validation of Alternative
Methods (now known as the European Union Reference Laboratory for Alternatives to
Animal Testing). The panel was convened in response to a request by the U.S. Environmental
Protection Agency for ICCVAM to evaluate the usefulness and limitations of
in vitro ocular safety testing methods. The panel's conclusions and recommendations
are contained in the
Expert Panel Report
 published in March 2005.
The Panel reconvened for a teleconference in September 2005 to consider additional data and information.
An Addendum to the Expert Panel Report, covering discussions
at the September 2005 teleconference, was published in November 2005.
ICCVAM and its Ocular Toxicity Working Group considered the Expert Panel Report and Addendum,
as well as public comments and comments of its scientific advisory committee, in developing
final recommendations on the four test methods.
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