National Toxicology Program

Test Method Evaluation Report

ICCVAM Test Method Evaluation Report: Identifying Chemical Eye Hazards with Fewer Animals NIH Publication No. 12-7930 Download complete report Large files may take some time to download: times will vary based on the speed of the online connection. The complete report file may not be accessible to all readers; files of individual sections of the report linked below may provide improved accessibility. If you would like assistance in accessing this document, please send an email to the ICCVAM Webmaster [Send Email] or call NICEATM at 919-316-4729. View Test Method Evaluation Report by Section Front Matter and Main Body Front Matter: Table of Contents, Lists of Tables and Figures, List of Abbreviations and Acronyms, Acknowledgements, Preface, and Executive Summary Section 1: Introduction Section 2: ICCVAM Recommendations: Identifying Chemical Eye Hazards with Fewer Animals Section 3: Analysis Supporting the Use of Fewer Animals for Evaluating Eye Hazards Section 4: ICCVAM Consideration of Public and SACATM Comments Section 5: References

Appendix A: ICCVAM Evaluation Timeline

Appendix B: Federal Register Notices and Public Comments

• Appendix B1: 75 FR 26757 (May 12, 2010): Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM)
  • Federal Register Notice
  • Responses to 75 FR 26757 (no responses received)


• Appendix B2: 76 FR 50220 (August 12, 2011): Availability of Draft ICCVAM Recommendations on Using Fewer Animals to Identify Chemical Eye Hazards: Revised Criteria Necessary to Maintain Equivalent Hazard Classification
  • Federal Register Notice - View notice as webpage
  • View responses to 76 FR 50220


• Appendix B3: Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) Comments: SACATM Meeting on June 17-18, 2010
  View relevant excerpts from SACATM Minutes
  Full meeting minutes available on U.S. National Toxicology Program website: refer to materials for 2010 meeting


• Appendix B4: Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) Comments: SACATM Meeting on June 16-17, 2011
  View relevant excerpts from SACATM Minutes ]
  Full meeting minutes available on U.S. National Toxicology Program website: refer to materials for 2011 meeting

Appendix C: Ocular Toxicity Regulations and Guidelines

• Appendix C1 : Table of Relevant U.S. Federal and International Ocular Testing Regulations for Hazard Classification and Labeling
• Appendix C2: Federal Hazardous Substances Act - Public Law 86-613; 15 U.S.C. 1261-1278
  View on U.S. Consumer Product Safety Commission website
• Appendix C3 : Organisation for Economic Co-operation and Development Test Guideline 405: Acute Eye Irritation/Corrosion
• Appendix C4: Test for Eye Irritants (16 CFR 1500.42)
  View on U.S. Government Printing Office FDSys Website - View as webpage
• Appendix C5 : U.S. Environmental Protection Agency Office of Prevention, Pesticides, and Toxic Substances Guidance Document 870.2400
• Appendix C6: U.S. Environmental Protection Agency Label Review Manual
  View on U.S. Environmental Protection Agency website